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For Keratosis "I will give this medicine a higher rating perhaps when I finish the treatment.
Mendenhall et al found that patients with radiologic evidence of PNI without clinical symptoms had a higher cure rate using surgery and postoperative irradiation compared to patients with clinical symptoms (80% vs 45%).
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Sub-clinical AK lesions may become apparent in the treatment area during treatment and may subsequently resolve.
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The present invention is directed to the use of complementary or combination lesion-directed therapy, such as cryosurgery, and field-directed therapy, such as low dose imiquimod topical therapy with short durations, in combination to treat actinic keratosis (“AK”).
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Widely scarred areas can be treated by excision of the entire scar and providing cover by split skin graft (SSG), full thickness skin graft (FTSG), or a flap.
Treatment with imiquimod cream can be resumed after the skin reaction has subsided, as determined by the physician.
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Given the pleiotropic effects of imiquimod, Dewan and colleagues could not conclude whether the modulation of lymphocyte recruitment, angiogenesis inhibition, or T-cell function influenced the observed efficacy.
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During the entire 17 weeks, the 79 year old white male is monitored for total or partial clearance, local skin reactions, including erythema, and adverse events at (a) baseline, (b) week 3, (c) week 9 and (d) week 17.
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Creates cytotoxic oxygen species and free radicals, which selectively destroy rapidly proliferating cells.
Interpretation and extrapolation of results obtained with cell lines to primary cell populations or either of these to whole organisms and vice versa merit consideration of the characteristics and limitations of each model system.